![]() ![]() ![]() Liu was born in Beijing and had a successful junior career where she won several tournaments in the U.S. 2013.Yu Liu (born 15 November 1995) is a Chinese professional golfer and member of the LPGA Tour. Oct4 and canonical Wnt signaling regulate the cardiac lineage factor Mesp1 through a Tcf/Lef-Oct4 composite element. Li Y, Yu W, Cooney AJ, Schwartz RJ, Liu Y.Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Liu Y, Kaneda R, Leja TW, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz RJ, Barahona M, and Schneider MD.Celf1 regulates cell cycle and is partially responsible for defective myoblast differentiation in myotonic dystrophy RNA toxicity. Peng X, Shen X, Chen X, Liang R, Azares AR, Liu Y.Genome-wide identification of MESP1 targets demonstrates primary regulation over mesendoderm gene activity. Soibam B, Benham A, Kim J, Weng K-C, Yang L, Xu X, Robertson M, Azares A, Cooney AJ, Schwartz RJ, and Liu Y.Modeling myotonic dystrophy 1 in C2C12 myoblast cells. Liang R, Dong W, Shen X, Peng X, and Liu Y.The all chemical approach: A solution for converting fibroblasts into myocytes. Mesp1 marked cardiac progenitor cells repair infarcted mouse hearts. Liu Y, Chen L, Diaz AD, Benham A, Xu X, Wijaya C, Luo W, Soibam B, Prejusa A, Yu W, Guanaratne P, Cooney A, McConnell BK, Schwartz RJ.The miR-322/503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. Shen X, Soibam B, Benham A, Xu X, Chopra M, Peng X, Yu W, Bao W, Liang R, Azares A, Gunaratne HP, Mercola M, Cooney AJ, Schwartz R, and Liu Y.Earlier and broader roles of Mesp1 in cardiovascular development. An improved method with high sensitivity and low background in detecting low b-galactosidase expression in mouse embryos. Shen X, Bao W, Yu W, Liang R, Nguyen B, and Liu Y.Tcf7l1 Directly Regulates Cardiomyocyte Differentiation in Embryonic Stem Cells. Coregulatory long non-coding RNA and protein coding genes in serum starved cells. Wang F, Liang R, Soibam B, Yang J, and Liu Y.H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity, and metabolism. Wang F, Liang R, Tandon N, Matthews ER, Shrestha S, Yang J, Soibam B, Yang J, Liu Y.doi:10.1093/nar/gkz315 * co-corresponding authors Accurate prediction of boundaries of high resolution topologically associated domains (TADs) in fruit flies using deep learning. Henderson J, Ly V, Olichwier S, Chainani P, Liu Y*, Soibam B*.Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. Tandon N, Goller K, Wang F, Soibam B, Gagea M, Jain AK, Schwartz RJ, Liu Y.Currently, Liu is using animal models to address how ectopic expression (transgenic) or deletion (knockout) of miR-322/503 affects normal heart function and the outcome of ischemic heart diseases. Next, they learned that triggering the expression of miR-322/503 was sufficient to drive heart muscle cell differentiation in a cell culture system. Using mouse genetic tools, the lab identified miR-322/503 as one of highest enriched microRNA clusters in early heart progenitor cells. Liu’s recent work on miR-322/503 exemplifies a typical approach. By learning these processes, Liu hopes to provide unique insights into human diseases and develop novel approaches to treat them. At the early stages of life when the embryo comprises only a few hundreds of cells, cellular differentiation and organogenesis are highly dynamic and regulated by powerful factors such as pioneer transcription factors and non-coding RNAs. Yu Liu is interested in the regulatory mechanisms of early embryonic development. ![]()
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